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Delirium and cognitive disorders



Aspects of dementia and deliriumtop

  • consensus Alzheimer's Disease

    National Institute of Health consensus Alzheimer Disease April 26-28 2010

  • www.alzforum.org
  • Alzheimer's Disease Research Center (CDR)

    From Washington Universty in St Louis, contains all information on the Clinical Dementia Rating Assessment

  • Association for frontotemporal dementia

    Educate physicians and allied health professionals about frontotemporal degeneration and how to improve patient care

    Medical Advisory Council members are among the foremost leaders in FTD research and clinical management. Promote and fund research into finding the cause, therapies and cures for frontotemporal degeneration

  • Mayo Clinics website for frontotemporal dementia
  • NINDS.NIH Pick's Disease

    information on Pick's disease

  • University of Nottingham: LewyNet

    It provides information on dementia with Lewy bodies.

  • The Whole Brain Atlas

    Provides a lot of information about imaging techniques, normal brain structures, and findings associated with various brain disorders.

  • www.icudelirium.org
  • European Delirium Association
  • site Sharon K.Inouye
    The Hospital Elder Life Program (HELP)
    Developed by Dr. Sharon K. Inouye and colleagues at the Yale University School of Medicine. This website provides information about recognizing delirium (new mental confusion). It also describes a program that prevents delirium in hospitalized older people, the Hospital Elder Life Program, or HELP. It is partly intended for patients and caregivers, but also provides useful links to other websites on this issue for physicians and investigators. A very convenient bibliography provides a searchable database of articles and book chapters on delirium and acute hospital care of older persons which is primarily intended for clinicians and researchers interested in exploring these topics.

     

  • the DDMED website.

    The site provides tools for assessment, behavioural, medical and  pharmacological management of adult persons with Development Disorders and Mental Retardation in case of aggressive behaviour, self-injurious behaviour, faecal smearing, pica, screaming and delirium.


Criteria for various forms of dementiatop


Measurement Instrumentstop

  • Cornell Scale for Depression in Dementia

    Alexopoulos, G.S., Abrams, R.C., Young, R.C. & Shamoian, C.A. (1988). Cornell Scale for Depression in Dementia. Biological Psychiatry, 23, 271-284.

  • Delirium Rating Scale-98-N

    Trzepacz, P.T., Baker, R.W. & Greenhouse, J. (1998) A symptom rating scale for delirium. Psychiatry Research, 23, 89-97.


Guidelinestop

  • APA Alzheimer's and other dementias: Guideline Watch

    Guideline Watch. Practice Guideline for the Treatment of Patients With Alzheimer⦥uro;?s Disease and Other Dementias of Late Life. 

    This APA document (Augustus 2004) includes relevant information that has come to light since publication of the guideline in 1997.

  • APA delirium guideline (1999)

    Practice Guideline For the Treatment of Patients with Delirium of the American Psychiatric Association (APA).

  • APA delirium guideline: Guideline Watch

    Guideline Watch. Practice Guideline for the Treatment of Patients With Delirium.

    This APA document (Augustus 2004) includes relevant information that has come to light since publication of the guideline in 1999.


Journalstop


Survey articlestop


the interface of dementiastop

In this subsection interesting articles on the interface of several dementia's will be presented. These can be either theory-based papers or articles presenting clinically diversity in cases in one family or group.


immunologically mediated cognitive declinetop

An exciting new field of interest in cognitive decline are the immunulogically mediated delirium and dementias. These can occur without cancer association and are curable!In contrast to classical paraneoplastic encephalitides which are intracellular and T-cell mediated these novel group disorders are associated with autoantigens on the cell or synaptic surfaces directly mediated by antibodies

Many encephalitides once considered idiopathic are now thought to be immune-mediated. One such disorder  predominantly affects structures of the limbic system, including the medial temporal lobes, the amygdala, hippocampus and orbitofrontal cortex. Faetures are short-term memory deficits, emotional and behavioral disturbances, such as confusion, irritability, depression, sleepdisturbances, seizures and dementia

 


cognitive impairment exercise and inflammationtop

Several neurodegenerative diseases are linked to inflammation. Interleukine 1β and TNF-α-related-apoptose-inducing ligand (TRAIL), and other cytokines are thought to be involved in the aetiology of Alzheimer's disease. This is also true for amyloid β which itself has inflammatory effects. The progression of neurodegeneration in neurodegenerative diseases is further promoted by systemic inflammation. In a complex manner physical activity is linked to immunity and inflammation.

  • Cognitive impairment, exercise and infammation

    In this Nature article the transcriptional coactivator PGC1α,  α factor that has recently been shown to regulate several exercise-associated aspects of muscle function, is proposed to control muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.